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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

The Veterans Day holiday, which pays tribute to all men and women who have served in the U.S. military, dates back to 1919, when President Woodrow Wilson proclaimed November 11 as Armistice Day to celebrate the end of fighting exactly one year earlier in World War One - "the war to end all wars" - between Germany and the allied nations of Britain, France and the United States. The armistice famously went into effect at "the eleventh hour of the eleventh day of the eleventh month."
这需要领导人具备不同的技能——尤其需要领导人对组织的共同目标具有更清晰的视野。在新的一年,如何领导由机器人和人类组成的“团队”的困境将变得更为紧迫。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Since merged airlines often continue to report delay statistics separately, it may take a few years to see how the new American does during holiday travel.
在1月10日发表的一条推文中,奥巴马写道:“感谢你们为我做的一切。我最后一个请求和第一个一样。我请求你们不要相信我的而要相信你们自己的创造改变的能力。”

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Some industries will likely pick up faster than others. Industries such as construction and manufacturing will probably begin to hire sooner. Retail, tourism, and hospitality, which depend entirely on consumer spending, will probably be among the last to recover.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

读:挨批课。上课时赶上老师心情不好,念一段巨长的诗史批评你。这种方法确实是超凡脱俗,不同一般。E张黄色pic-超凡脱俗,不同一般的

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

这部电影人们期待已久。无论对蝙蝠侠粉还是超人粉来说,该片都将是一场视觉盛宴。 我们知道,蝙蝠侠将在片中打败超人,但他究竟是怎么做到的呢?
Graduates in economics and finance still have great prospects for making big money, the National Business Daily reported, citing a new survey. The average monthly salary for graduates from five major Chinese universities in finance and economics stayed above 10,000 yuan.
谷歌2017搜索排名靠前的包括马特·劳尔和飓风厄玛。搜索巨头公布了它今年的年度搜索结果榜单,内容主要是在全球各类行业中谷歌搜索排名靠前的几位。
个人电脑使用周期延长,再加上智能手机和平板电脑带来的竞争,大大抑制消了消费者对PC的需求。据IDC数据显示,全球各地区的电脑出货量均连续5个季度出现下滑。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

'In the next 12 to 24 months, unless any of these bottlenecks are solved, we could see WTI going down to $50 a barrel, to incentivize producers to slow down,' she said
8.Form or Join a Study Group
创造一个学习空间,来帮助你最大限度地利用好学习时间。你是喜欢绝对的安静,抑或吵闹的音乐呢?你是喜欢在餐桌上办公,还是想关上门创造了一个安静的空间。理解你喜欢的类型,并创造属于自己的空间。
adj. 突出的,显著的,未支付的

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

absolutely

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

2. 宾夕法尼亚大学沃顿商学院

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Mr Lam predicts that any recovery in the market will rely on appetite from cash-rich companies from mainland China, with foreign investors restricting their investments to real estate investment trusts or stocks exposed to developers, rather than actual property.
巴尼汤普森(Barney Thompson)是法律记者

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 小区业主卖房时联合涨价是否违法
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

单词compromise 联想记忆:
13. “Girlhood” (Céline Sciamma)

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

The board is frequently covered in equations. Have you ever wondered what those equations mean? Well, we may never know what they mean, but they are all real, accurate equations. Very impressive, Big Bang. Very impressive indeed.
Chinese exports rose at more than twice the rate expected in November, boosting the country’s trade surplus.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

什么温度的葡萄酒最好喝(图)
Men and women rated the strengths of their programme equally.
据中国互联网络信息中心发布的一份报告显示,截止2016年12月,中国网民数量已经达到了7.31亿人,这一数字差不多相当于整个欧洲的全部人口。
The diplomatic row began when Ankara’s foreign minister was denied entry to the Netherlands on Saturday for a campaign rally in favour of Mr Erdogan’s constitutional reforms. Armed Dutch police also intercepted another Turkish minister, Fatma Betul Sayan Kaya, on her way to the rally in Rotterdam and escorted her back to the German border.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 不必改为个人收入调节税
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

cred相信+it表名词,通常是抽象名词→相信

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

9月份CPI录得1.6%的同比涨幅后,经济学家曾预测10月份的同比涨幅为1.5%。中国政府为今年全年设定的通胀目标为“3%左右”。
在9月初发布的另一份报告中,世界气象组织(World Meteorological Organization)称,2013年大气中的二氧化碳水平,比工业革命之前的普遍水平高出42%。其他重要的温室气体含量也有所增加,与前工业化时代水平相比,甲烷增加了153%,一氧化二氮增加了21%。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: 自贸试验区改革创新不能止步
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

adj. 投影的,投射 v. 投射(project的过去

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

工业企业利润由上年下降2.3%转为增长8.5%;

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

10) I often make a fuss about unimportant things 0 1 2 3 4
有理由怀疑纳伦斯-诺埃尔是否能成长为可靠的先发中锋,这些理由包括他的伤病史、场外红灯行为和非常有限的进攻手段。
This post is in partnership with Entrepreneur. The article below was originally published atEntrepreneur.com.
China's employment situation is generally stable in the first quarter of 2016, said Li Zhong, Spokesman of the Ministry, adding that the economic downturn and structural reform, however, make employment more difficult.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

Over at Huffington Post Mark Gongloff warns: That 'dramatic downgrade of U.S. economic growth in the first quarter revealed the economy's lingering weakness, exposed the folly of Washington's austerity obsession and slapped the Federal Reserve's newfound optimism right in the face.' And with politics deteriorating, it'll get worse.
为大批来自欧洲经济区以外的学生安排签证难度较大,这在一定程度上解释了为何英国商学院在国际课程经验方面表现奇差,有14所英国商学院位于这项指标排名的后半部分。
Don't accept an Offer Accept Immediately
一位本田高管私下里将该公司的很多问题归咎于“运气不好”,而不是内部管理不当或有意失职。也许确实如此。不过本田管理层确实应该认真反省,反复自查,并控制好其管理系统和生产流程,确保客户好感度不再每况愈下。(财富中文网)
单词exceed 联想记忆:

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

designated
STEP 10: Even if you don't really fit the criteria, tell everyone you are a SOCIOPATH

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 美涂士漆石家庄正定店全新开业
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Rank: 5

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Finding the skill sets and attitudes that support the culture of the brand you want to promote will foster innovation and enhance your reputation. Include folks from outside the company for the people you rely on. That will start a free marketing chain reaction that can build confidence and revenue.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

12. 最有希望的迹象。有段时间,你会觉得现状已经改善了,人们可以公开大声谈及业内的歧视现象。维奥拉·戴维斯(Viola Davis)出来说话,詹妮弗·劳伦斯(Jennifer Lawrence)公开谈起,自己比片中的合作男星片酬少。“我不想被视为‘难搞’或者‘被宠坏了’,”她在简报《伦尼》(Lenny)中为许多人发言,其中包括许多薪酬更低的人们。
To Anita Eerland and Rolf Zwaan [THE NETHERLANDS] and Tulio Guadalupe [PERU, RUSSIA, and THE NETHERLANDS] for their study “Leaning to the Left Makes the Eiffel Tower Seem Smaller."
游戏平台:Xbox One
单词pandemic 联想记忆:

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

007系列电影主题曲第十名:雪莉·巴赛--《永远的钻石》
n. 火
Many are less than impressed by the cheesy indulgence, with the New York Daily News speaking to one dietitian who blasted the lack of nutritional value in the pizza's most expensive ingredient: the Ecuador-imported gold flakes.
就业增长超出预期;

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

7.狱警
Today's and tomorrow's technology sits on top of multiple layers, every one of which is changing and has to inter-operate with others. This makes our gadgets, the internet of things, phones and laptops unstable. And it makes consumers irritated. How many of your apps actually work--and actually make life easier, faster or more fun? I'd expect to see consumer cynicism grow, as delight is overtaken by disappointment. This will put pressure on hardware and software developers to deliver that most boring of qualities: reliability.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

PBS' 'Vietnam War' series receives a special award.
5. Life is like a coffee table: it’s got tea sets and dinnerware all over it. (beiju, 杯具, is a homophone for tragedy, 悲剧, and dinnerware, canju, 餐具, a homophone for disaster, 惨剧).
《大汉情缘之云中歌》
Blue skies will not be, and should not be, a luxury.
The research also suggests there maybe a value in finding a job through an internship. Interns who accepted a job offer had higher salaries than those who had received an offer but refused it. Those interns who did not receive an offer had lower salaries still. The gap between these groups had increased three years after graduation.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

"It became an issue about so many things, such as the environment, energy, workplace disasters and the role of big government. It became a lightning rodfor peoples' anxieties," she explained.
Among these six US schools, Rutgers Business School in New Jersey is the highest new entrant at 70. WP Carey School of Business at Arizona State University is the highest returning school at 57. Moore School of Business at the University of South Carolina returns at 77. Moore stands out for being top overall for international course experience. Its students spend from several months to a year overseas.
circ圆,环+ulate→绕圈走→循环,流通

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 业主们 这些隐形收益你们知道吗
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

“伦敦商学院拥有优秀的学员群体,国籍非常多样化,具有竞争力和聪明才智,”一位2012级的美国毕业学员评论道:“它也给了我无需参加单纯聚焦美国的美国MBA课程就能(通过交换)在美国学习的机会。”
我发现自己经常担心一些事情

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 木制品甲醛国标亟待升级
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

这会吓走一些人,这些人不了解你更好。
[.impre'sɑ:ri?u]
Countrywide, month-on-month prices rose in 59 out of 70 cities last month – down from 62 – were unchanged in four and fell in eleven. Cities where prices fell from the previous month included Shenzhen (down 0.3 per cent), Hangzhou (down 0.4 per cent) and Xiamen (down 0.2 per cent).

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Gitanjali表示,她想要进一步改善改设备,这样它最终就能进入市场了。
adv. 最初,开头
“This is a historic moment for Puerto Rico,” said 50-year-old Jose Davila as he waved a large flag from Rossello’s pro-statehood party. “He’s the hope of our island, he’s the hope for statehood, he’s the hope for a people that have suffered.”

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 从“囤房”到“以房养老”有多远
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

The remarks by Recep Tayyip Erdogan come less than 24 hours before Dutch voters go to the polls in a national election that has been coloured by a heated debate about the role of Islam in Dutch society, spurred by anti-Islam candidate Geert Wilders. Mr Wilders’ Freedom party (PVV) is polling second in the race.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

周三,北京市市委宣布,计划将绝大部分的北京市政府部门在2017年迁至通州区。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

据行业估计,到2020年,我国年度票房有望达到1000亿元人民币。
由于新出口订单增幅与上月基本持平,新订单总量增长趋缓。但就业流失加速,投入品价格增幅收窄,企业对客户收取的价格略有回升。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

“I was quite sceptical initially in doing an online course but the communication and online interaction were perfect,” says one graduate from AGSM.
However, another 876 jobs being offered have not registered a single applicant as of Tuesday, according to Zhonggong. For instance, nobody has so far shown any interest in becoming a railway police officer in Shanghai and Xi'an.
在中国,微信还吸引了越来越多的高端用户。腾讯过去在这个群体当中并没有多高的份额。
这种旅行枕可以随意弯曲变形,您的头怎么放都行。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

对于上周有媒体称三星和黑莓正在进行收购洽淡的报道,两家公司都迅速予以否认。但全球最大的智能手机厂商为何愿意付出传闻中的75亿美元高价,来收购一家盛年不再的加拿大技术公司呢?答案是:因为后者持有丰富的知识产权——尤其是在前景光明的安全创新领域。
美联储政策中任何意外举动的潜在影响,在2013年的“缩减恐慌”(taper tantrum)中表露无遗,当时,仅是美联储可能很快缩减其超宽松货币政策力度的暗示就足以引发一波全球恐慌。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

That's not even a sarcastic quip, it's the truth.
The future is always bright if you are an entrepreneur, and the opportunities to create new ventures based on the digitisation of age-old services has a long way to run.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Gitanjali因为拿下了本次最高奖项,从而获得了一笔2.5万美元的奖金。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

“双创”是有着很强的生命力的。
It Pays to Get Along
The results are based on a survey of 15,870 people across the country in August and September.
We think of the passage of NBA time in seasons, for obvious reasons. There's connection, a continuum. It's how we remember things that happen, in the course of a season of play. But there's some benefit to looking back at a calendar year, January 1 to December 31, and what we've learned in that process. After all, many say the "unofficial start" to the NBA season is Christmas, with the new year starting soon after. So here are the lessons we learned about the NBA in the year 2017.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

We will continue to transform government function.
当你走进来的时候,我对你的认识比你的想象中的多。我在网上寻找关于你的资料,利用我自己的关系网来做面试前的背景调查。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

社交网络公司Facebook 、电子商务巨头亚马逊和玩具公司乐高则是品牌价值增幅最大的企业。
Financial advisors and asset allocators who had been hoping to see some benefit this year from tactical strategies were also not spared the punishment of a capricious market. Of the top three tactical strategies in the country (Mainstay Marketfield, Good Harbor U.S. Tactical Core, F-Squared Premium AlphaSector Index), two had nearly imploded with double-digit losses while the third found itself under SEC investigation for misleading the public about its historical returns. The other giant tactical manager, Schwab’s $9 billion Windhaven Diversified Growth product, looks to end 2014 with a return close to zero. So much for tactics.
其中,国产动作片《战狼2》位居榜首,成了中国史上收入最高的影片,门票销售狂揽56.8亿元。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Here are five things consumers and investors can count on (probably) in 2015:
File this under "great, yet stupid gift ideas." The BOx bottle opener claims to be the "world's first smart bottle opener" but it's not groundbreaking. This bottle opener sends a message to your friends via Messenger every time you open a bottle — crazy, right?
中国力争达成自己的亚太区协议

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 传统家居业O2O前景尚不明朗
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

“如果我们能找到在两个地方都购物的人,那就非常有价值。你知道他们是谁,他们买什么,他们哪些方面花钱,”哈勃补充说。“你可以给他们更加个人化的体验。”
达奇斯说:强大的财务性能和一系列新的特性使得邻客音成为2012年吸引用户的公司。这样的吸引力有助于公司在2013年从专业的业务网络转向活跃的交流平台。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 为城市管理装好“操作系统”
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

答:其实我并不怎么关心作品火不火的,就是专注于自己的作品而已。每次我关注的就是要怎样用最好地推进剧情而已。我关注的是行为和故事,不是受欢迎程度。
在弗丽达·詹尼尼(Frida Giannini)为古驰(Gucci)设计的很多时装秀上都可以看到这种理念,包括2014年秋冬的台布渐变色和A字皮裙;2013年春夏的粉色长款衬衫和褶饰女主人连衣裙;2009年春夏的披头士风格鲜艳裤套装和宽松束腰长裙。
国家统计局日前在其网站发布了上述数据,称这是科技研发经费增速连续4年下滑后的首次回升。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

About 980 million yuan of illicit assets were recovered, according to the Communist Party of China Central Commission for Discipline Inspection.
For the first time a Bond girl’s storyline will be followed beyond her fleeting experience with 007, with the return of Pussy Galore.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

'My first duty, my first responsibility was to be true to the original feel of the book, to be true to Ian Fleming: his creation, his world and his ideas.
上周,卢彦被任命为北京市推进京津冀协同发展领导小组办公室主任,该举措是为了加速京津冀一体化的协调工作。
8.保持微笑,处分是我支持的队伍丢掉了比赛。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

"某时,世界呈现给我们是相互分隔的,但是这些电影和电视作品让我们感觉世界是相通的,"美国电影学院的总裁兼首席执行官Bob Gazzale如是说。"美国电影学院奖表彰这些电影艺术家们,勇于挑战,让我们受到鼓舞,娱乐,又励志,最后让我们意识到,我们都有着同样的心跳,"

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Dachis says: Adidas added more than 34 million new fans and followers in just 12 months this year. The company put that audience to good use and benefited from high levels of positive discussion all year long.
8.Prosthetic Hands That Sense Touch

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

The surviving cat, since named Trooper, has recovered and found a new home.
senior

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 家居O2O:期待新的玩法和可能
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

活跃的ETF市场将取决于基于收费的分销网络的发展。富达国际(Fidelity International)亚太区董事总经理陶博宏(Mark Talbot)表示,分销基础设施正抑制零售需求。
And this year, the Nobel Prize has defied the convention of celebrating big by presenting the biggest prizes to discoveries on the smallest scales.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

研究人员写到,对于1700年前的中国朝代来说,如果能征服并有效的管理龟兹的话,那么他们就能够控制住西域所有的绿洲城邦。
With interest rates expected to rise only slowly, commodities are likely to attract hedge funds and other speculative investors looking for juicier returns, said the bank.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

1. China’s leadershipwill ignite the capital economy, funding an aggressive growth program withmajor infrastructure investments to support urban development, including hugeallotments for housing, schools, roads, and more.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

3. Dan Weiss “Fourteen” (Pi Recordings) There’s so much in “Fourteen,” the album-length composition by the drummer Dan Weiss: meticulous chamber maneuvers; avant-garde yowling; wordless vocals of new-music and northern Indian pedigree. More impressive than the expansive frame of reference is the fact that Mr. Weiss, marshaling about a dozen of his peers, spins it all into a flowing fabric.
Winners: Raptors
In the foreseeable future, China will see the boom of enterprises in tertiary industry. Related majors, including law, journalism and communication, and management, are expected to play a bigger role, according to the report.
New Year should be a time of banked-up fines, the scent of flowers and wine, good talk, good memories and loyalties renewed. But if all else is lacking - love will do.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: “房住不炒”稳步释放自住需求
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

今年8月,来自托雷维耶哈的乔斯·哈维尔创建了一个AdWords账户,这是谷歌旗下的一项点击付费服务。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Zhou Qunfei from Lens Technology, the major touchscreen maker, ranks third on the list with a net worth of 45 billion yuan.
他在最后一刻选择了教育慈善机构Teach First,后者如今已经成为英国招聘新毕业生最多的机构。雷文斯克罗夫特没有空降至需要重组的公司,而是开始在波尔主教学校(Cardinal Pole School)教授商业和经济学,该校主要招收伦敦东部哈克尼区(Hackney)11岁至19岁之间的青少年。
今年剩余时间将是大西洋两岸首次公开发行(IPO)的繁忙季节,意大利倍耐力(Pirelli)(见题图)、阿里巴巴(Alibaba)支持的百世物流(Best Logistics)和视频流媒体平台Roku等公司都将上市。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

I experienced this pessimism personally in Davos in January 2014. Several leading western intellectuals asked me whether war would break out between China and Japan. I was so confident that there would be no war in east Asia that I offered to take bets with ten-to-one odds against myself with eminent western journalists. Two took up my bets. And I will be collecting on these bets when I return to Davos in January.
Three leading energy agencies recently said production from outside the Organization of the Petroleum Exporting Countries would increase this year, much of it from U.S. shale. Added to that is the possible return to market of millions of Middle East barrels as Iran, Iraq and Libya potentially ramp up production. All of that is set to press on prices.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

It’s wall-to-wall pure pop heaven, crackling with originality and dark humor, teeming with action sequences so perfectly timed and executed you almost want to run out of the theater on the spot so you can call a friend and rave about it — but you wouldn’t dare leave your seat because you wouldn’t want to miss a frame of this brilliant, pulse-quickening gem.
1. Buy expensive tailored clothing that only sort of fits so that most of the time your buttons appear to be just seconds from bursting.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
From the themed collection: 家居企业抱团征战四万亿家居市场
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

单词unique 联想记忆:

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

PBS' 'Vietnam War' series receives a special award.
This founding father argued that the college would both guard against the desire in foreign powers to gain an improper ascendant in our councils and ensure the office of President will never fall to the lot of any man who is not in an eminent degree endowed with the requisite qualifications.
prosperity

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Xinhua reported in 2015 that the MOE and five other central government departments were putting together a task force to ensure that football thrives in the country's schools.
Chris Paul
野村证券(Nomura)的分析师表示:“我们预期这一轮出口增长的反弹不会维持很长时间,未来数月增长势头将恢复温和,原因是人民币的升值可能弱化中国的出口竞争力,且即使习主席和特朗普总统近期在北京会面,发生贸易摩擦的潜在风险并未显著减轻。”
全球化和世界的和平发展合作是一体的、不可分的。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

5. 《卡罗尔》,导演:托德·海因斯。
2017年度国家公务员考试网上报名于上周六开始。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

其他两家手机制造商OPPO和vivo的增长率都超过了100%,在2016年分别出货9940万台和7730万台。
Landline
该排名衡量的是欧洲商学院研究生课程的质量和广度。商学院必须参与所有这4项排名,才有资格获得完整得分。伦敦商学院去年排名第三,为首次参与所有4项排名。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

Goldie Blox是一家玩具公司,使命是重新定义玩具商店中的“粉红走道”。在科学、技术、工程和数学(STEM)教育和职业领域,男性数量要大大多于女性,大部分女孩往往在八岁前就对这些领域失去了兴趣。Goldie Blox所设计的玩具则通过吸引女孩发展强大的口头及故事讲述能力的方式——同时仍提供机会来发展日后可转化成对工程学兴趣的技能——来鼓励和启发未来的工程师们。说到机会,一家玩具初创企业如何能在和一开始就统治着玩具行业的大公司的抗衡中脱颖而出呢?Goldie Blox走出了明智的一步:最近,该公司发布了一段视频,采用了Beastie Boys的歌曲《女孩们》(Girls)做背景音乐,该视频得到了病毒式传播。尽管这段视频最终被撤下,但Goldie Blox在提高公众对让更多女性和女孩对STEM产生兴趣——以及对Goldie Blox玩具——的认知上,做了一份相当不错的工作。
It also said 98 percent of government-sponsored students returned to China. Government-sponsored students who study abroad have chosen to pursue disciplines most needed in China, including engineering, the pure sciences, agriculture and medical science.

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